R&D PROJECTS | telemedvet

EQUINE NUCLEAR

RADIOMICS & AI

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Several scientific equine projects are underway at our new purpose built Equine Research & Development Centre on Epsom Ave, Ascot. Western Australia.

Collaborating with leading equine veterinarians and universities both here and abroad we seek to bring together the best minds and state-of-the-art imaging technology to get a better understanding of the pathophysiological processes that lead to lameness and fatigue fractures.

The research projects include:

AI-Based Lameness Predictor for Thoroughbred Horses.

The aim of this project is to investigate the feasibility of using artificial intelligence – specifically, deep neural networks – applied to video of horse movement to quantify lameness and injury risk. Working in collaboration with Dr Andre Kyme of the Biomedical Engineering Faculty, The University of Sydney our first objective is to develop a convolutional neural network trained on consensus 5-point grading scores from multiple experienced observers, and to validate the accuracy of this model on unseen data. A subsequent objective is to refine the model training and validation using the ground-truth findings from clinical imaging.

Ethics Approved In compliance with Section 27 of the NSW Animal Research Act 1985, this Animal Research Authority (ARA) remains in force for a period of 12 months, unless cancelled sooner. Project number: 2020/1846

Relationship between serum biomarkers and equine nuclear medicine radionomics in the prediction of lameness and fracture.

The purpose of this study is to evaluate the usefulness of measuring serum bone turnover markers in risk stratifying ENM scans in association with radiomic analysis. This will be achieved with the following research objectives:

Examine the strength of the association of serum bone and cartilage biomarker (BCM) concentrations with increased radionuclide uptake in racing/training thoroughbreds.
To evaluate the prognostic value of concomitant BCM levels in the risk stratification of lameness and spontaneous bone failure.
Develop a radiomic platform to identify high-risk bone lesions, which may serve as a clinically useful predictive tool.

Current published research on these topics and other aligned studies into medical imaging and blood based biomarkers.

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Research Publications & Presentations

TeleMedVET & TeleMed

Real world experience with [99mTc]Tc-HYNIC-iPSMA SPECT prostate cancer detection: interim results from the global NOBLE registry. EJNMMI Rep. 2024 Dec 30;8(1):43.doi: 10.1186/s41824-024-00226-4.
ChatGPT and Patient Information in Nuclear Medicine: GPT-3.5 Versus GPT-4. Currie G, Robbie S, Tually P. J Nucl Med Technol. 2023 Dec 5;51(4):307-313. doi: 10.2967/jnmt.123.266151
Evaluation of treatment efficacy of radioactive iodine-131 treatment for feline hyperthyroidism: Western Australian experience." Currie, Geoff, Shiphra Tagore and Peter Tually. ANZSNM Annual Scientific Meeting. 2024.
Intelligent imaging: Applications of machine learning and deep learning in radiology. Currie, G. and Rohren, E., 2022. Veterinary Radiology & Ultrasound, 63, pp.880-888.
Elevated serum osteocalcin levels correlate positively with abnormal nuclear scintigrams in lame thoroughbred racehorses. Tually, P., Meadows, J., Currie, G., & Tagore, S. (2024). In 54th Annual Scientific Meeting of the Australian and New Zealand Society of Nuclear Medicine 2024: ANZSNM ASM 2024.
Concurrent measurement of serum and radiomic biomarkers in the clinical investigation of equine musculoskeletal injuries: A prospective pilot study.
Tually P, Currie G, Blache D, Meadows J, Gray C, Hemmings L, O'Callaghan P, Murphy D. Vet Radiol Ultrasound. 2023 May;64(3):484-491. doi: 10.1111/vru.13223. Epub 2023 Feb 28. PMID: 36853616
Potential utility of B-type natriuretic peptides in secondary prevention following percutaneous coronary intervention in remote communities of Western Australia.
Tually PJ, Currie G, Lenzo NP, Hendrie DV, Meadows JW, Janssen JHA. Biomarkers. 2023 Dec;28(5):458-465. doi: 10.1080/1354750X.2023.2209705. Epub 2023 May 11. PMID: 37128799
Single‐photon emission computed tomography of the pelvis and lumbar spine contributes to the diagnosis of injury in two horses. Harding, P. G., P. Tually, A. M. Cullimore, and Kathelijne Peremans. Equine Veterinary Education 34, no. 1 (2022): e27-e34.
Brain natriuretic peptides (BNP) associated with abnormal myocardial perfusion scintigraphy predict cardiac events in patients with known coronary artery disease: Value in secondary prevention in remote populations. Tually, P. Currie, G. Lenzo. N.Skelly, L.Meadows, J.Janssen, J. International Conference on Nuclear Cardiology and Cardiac CT , Vienna, May, 2017.
The Advanced Practitioner Role in the Medical Radiation Sciences; An Australian Perspective Skelly, L. Tually, P. Currie, G. 46th Scientific Meeting of the Australian and New Zealand Society of Nuclear Medicine, Rotorua, April 2016.
Implementation of a Telehealth Based Rural Nuclear Medicine Training Program for PDY/interns. An Assessment of a Pilot Study in Western Australia. Tually, P. Meadows, J. Hemmings, L. Lenzo, N. 5th Annual Meeting of the Australasian Telehealth Society. November 2014, South Australia, Australia.
Management of patients following percutaneous coronary interventions in rural centres of Australia: B-type natriuretic peptides (BNP) and myocardial perfusion single photon emission computed tomography (SPECT) in predicting repeat revascularisations. Tually, P. Lenzo. N. Henderson, A. Johnson, A. Janssen, J. American Society Nuclear Cardiology, 17th Annual Scientific Session, September 6-9, 2012 in Baltimore.
Implementation of computerised radiology order entry in an emergency department setting of an outer-metropolitan hospital and its impact on clinician referral practice. Tually, P.J, Bertke, C,Iyer, G, Heal, C, Moorin, R, Bairstow, P, Mendelson, R, Walker, J.D Royal Australian & New Zealand College of Radiology, National Conference, Perth, October 2010.
Methodology for the evaluation of telenuclear medicine and its effect on diagnostic management in regional and rural centres of Western Australia. Tually, PJ Paper acceptance, 10th National Rural Health Conference, Cairns 2009.
The impact of teleradiology in rural communities, the challenges Integrating private and public health systems and maintaining clinical quality. 4th International e-Health & Telemedicine Workshop. Centre for On-line Health, Perth, 2009.
Teleradiology – Benefits for rural communities, maintaining clinical quality and the challenges we face into the future. National Telemedicine Summit – Creating a Viable Alternative to Face-to-Face Medical Care, Sydney 2009.
Effect of Pharmacological Stress on N-Terminal Pro-Brain Natriuretic Peptide Concentrations in the Evaluation of Ischaemic Heart Disease Peter Tually, Nat Lenzo, John Walker, Stephen Hinton, Rachel Moorin, Johan Janssen Heart Lung and Circulation, ISSN: 1443-9506, Vol: 17, Issue: 3, Date: 2008-01-01, Page: S99
Ayers, M, Currie, G, Tually, P, Crook, C, Harrison, N, Robertson, C, Pearce, R & Grimmond, D 2008, Effective implementation of strategies for CPD by RAINS, Presented at the 2008 ANZSNM Annual Scientific Meeting, Gold Coast.
Tually, P, Currie, G, Ayers, M, Crook, C, Harrison, N, Robertson, C, Pearce, R & Grimmond, D 2008, A collegial strategic approach to professional isolation as a barrier to continuing professional development in rural Nuclear Medicine, Presented at the 2008 ANZSNM Annual Scientific Meeting, Gold Coast.
The Rural Alliance In Nuclear Scintigraphy (RAINS): Progress Report. G Currie, M Ayers, P Tually, R Pearce, M Crook, N Harrison, C Robertson, D Grimmond. The Internet Journal of Nuclear Medicine. 2007 Volume 5 Number 1.
Currie, G, Ayers, M, Robinson, C, Pearce, R, Tually, P, Crook, M & Harrison, N 2007, A collegial strategic approach to professional isolation as a barrier to continuing professional development in rural Nuclear Medicine, Presented at the 2007 NSW Rural Allied Health Conference, Dubbo.
User acceptance of the Web-based distribution of radiology services in regional and remote centres of Western Australia. Tually P. Stavrianou C. Walker J. [Evaluation Studies. Journal Article] Journal of Telemedicine & Telecare. 11 Suppl 2:S93-5, 2005.
Correlation between the concentration of B-type natriuretic peptide in plasma and Technetium-99m gated blood pool single photon emission computed tomography analysis in determining volume status in Aboriginal patients on chronic hemodialysis. Tually P.J., Janssen J.J., Henshaw D, Thomas, M., Bhagat, C, Walker, J.D. Imaging the South, Department of Medicine and Western Cardiology, Kalgoorlie Regional Hospital, WA. RACP National Conference, Canberra. 2004.
Internet based nuclear telecardiology supporting the clinical management of cardiac disease in a remote community. Peter Tually, Johan Janssen , David Henshaw, Kenneth Ng, Stephen Hinton and Johnny Walker. State Rural Health Conference, Department of Health, Western Australian Jan 31-Feb01 2003
A preliminary assessment of Internet-based nuclear telecardiology to support the clinical management of cardiac disease in a remote community.Tually P. Janssen J. Cowell S. Walker J. [Journal Article] Journal of Telemedicine & Telecare. 9 Suppl 1:S69-71, 2003.
Teleradiology in regional and rural centres of Western Australia – what is the real impact on patient management? Peter Tually, Ian Went, Kevin Jones, Kenneth Ng and Johnny Walker, State Rural Health Conference, Department of Health, Western Australian Jan 31-Feb01 2003
Renal dialysis and the assessment of cardiac function in the Aboriginal population by incorporating telemedicine analysis. Peter Tually, Johan Janssen , David Henshaw and Johnny Walker, State Rural Health Conference, Department of Health, Western Australian Jan 31-Feb01 2003
“Aussies test effect of nuclear medicine telediagnosis”. Diagnostic Imaging, May 19, 2003. http://www.diagnosticimaging.com/informatics-pacs/content/article/113619/1178107
The effect of nuclear medicine telediagnosis on diagnostic pathways and management in rural and remote regions of Western Australia. Tually P. Walker J. Cowell S. [Evaluation Studies. Journal Article] Journal of Telemedicine & Telecare. 7 Suppl 2:50-3, 2001.
Developing Practical Teleradiology for Effective Diagnostic Management in Regional and Remote Medicine and the Challenges that Lie Ahead. Walker, J. and Tually, P., 2001. PT4: Australasian Physical & Engineering Sciences in Medicine, 24(4), p.253.
Nuclear medicine teleradiology in regional and rural centres of Western Australia. Tually P. Parrish F. Walker J. [Case Reports. Journal Article] Journal of Telemedicine & Telecare. 5 Suppl 1:S47-50, 1999.
Technegas: Reduced radioactive contamination levels and improved delivery using an occlusive face mask. Poster No. 1535. Society of Nuclear Medicine, 44th Annual meeting 1997.